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2 Establishing the correct diagnosis of malignant peripheral nerve sheath tumor remains a challenge not only due to morphological and immunohistochemical complexity (particularly outside the NF1 context) but also because a number of other sarcomas, benign soft tissue tumors, and non-epithelial tumors (especially melanoma) can appear similar to malignant peripheral nerve sheath tumors

doi: 10.1186/s12951-025-03258-5 150 LinYJinJHanQHangDChenZYeSet al

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and c) reduced water absorption capacity of the large intestine and rectum and a weakened motility, thus making it susceptible to swelling and constipation (17)