At high doses (3,000 mg and up) there can be mild nausea, diarrhoea and a fishy body odour (from a breakdown product that the gut bacteria make)
Were not there yet, but were getting closer

Key points: People who received doses of retatrutide ranging from 1 mg (lowest dose) to 12 mg (highest dose) experienced significant weight loss compared to the placebo group At 24 weeks, the percentage change in body weight ranged from -7.2% in the 1 mg group to -17.5% in the 12 mg group, compared to -1.6% in the placebo group At 48 weeks, the percentage change in body weight ranged from -8.7% in the 1 mg group to -24.2% in the 12 mg group, compared to -2.1% in the placebo group A large proportion of people receiving retatrutide (64% to 100%) achieved an average weight loss of 5% or more, with some participants even losing 30% or more of their baseline weight Retatrutide treatment showed improvements in cholesterol levels, hypertension (high blood pressure) and blood glucose levels A recent paper published in The Lancet showed that combining retatrutide with lifestyle changes leads to significantly greater weight loss than lifestyle interventions without medication

This approach is designed to help individuals achieve safe and effective short-term weight loss
For a detailed explanation, check out this post: Summary: Gradual Performance Degradation: LiPo battery performance gradually degrades over time and usage