Higher weight loss (1% reduction in weight from baseline was associated with a 3.1% [95% CI, 2.9%-3.2%] lower hazard of discontinuation for patients with type 2 diabetes and a 3.3% [95% CI, 3.2%-3.5%] lower hazard of discontinuation for patients without type 2 diabetes) and higher income (type 2 diabetes only
Competition among GLP-1 drugs could have a moderating effect on launch prices and lead to higher rebates negotiated between manufacturers and pharmacy benefit managers
When either adjustment is used, the Low Dose remains 1.6 mg and the Elevated Dose remains 4.8 mg regardless of sex
Unsaturated VPA metabolites (4-en-VPA and 2, 4-dien-VPA) are potent inducers of microvesicular steatosis in rats, whereas VPA itself failed to induce discernible liver lesions at near lethal doses [60]
Specific subtypes assessed included Alzheimers disease, vascular dementia, frontotemporal dementia, Parkinsons disease, extrapyramidal and movement disorders, and dementia with Lewy bodies