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However, a meta-analysis reported that the use of NAC showed no significant improvement in pregnancy rate, serum LH level, fasting insulin, and LH/follicle-stimulating hormone (FSH) ratio despite that the BMI and total testosterone were significantly reduced (138)

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Perturbations of ER function cause ER stress leading to the unfolded protein response, which includes inhibition of protein synthesis, protein refolding, and clearance of misfolded proteins [75]

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Therefore, considering the widespread use of these medications, it is crucial to elucidate the potential role of GLP-1RA use in the development of thyroid cancer

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