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Melasma can be treated by drugs that inhibit melanin production by decreasing new melanin-producing cells and decreasing the proliferation of melanocytes

Metabolic reprogramming: Altered energy metabolism is one of the key cancer hallmarks, with the well-known example being the Warburg effect

Moreover, excess iron could promote the formation of reactive oxygen species (ROS), which can lead to oxidative stress and DNA damage, with cytokine-regulated inflammatory pathways and a central contribution from innate immune cells in the tumor microenvironment (360, 361)

Avoid both injectable and topical use in these populations without clinician oversight

Further studies in the 2000s, (7) suggested that the GHK-Cu peptide hosts the potential to not only stimulate the collagen synthesis but also stimulate the production of tissue inhibitors, TIMP-1 and TIMP-2