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It upregulates genes involved in collagen synthesis (COL1A1, COL3A1, COL5A1), extracellular matrix remodeling (decorin, fibromodulin), and antioxidant defense (superoxide dismutase, glutathione peroxidase) while simultaneously suppressing genes associated with inflammation (IL-6, TNF-alpha), fibrinogen production, and tissue destruction (several MMPs)
Both methods have their place in a comprehensive regenerative medicine protocol
For those without malabsorption, oral B12 supplements are generally preferred
Injectables require no routine maintenance
This is where B12 benefits can come into play
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