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Adverse reactions to drugs | Medicines guidance | BNF | NICE

Several CVOTs have demonstrated that GLP-1 RAs reduced CV risk in T2DM patients with established ASCVD or high CV risk independent of HbA1c levels

[PubMed] Gaiday AN, Tussupkaliyev ABT, Bermagambetova SK, et al.Effect of homocysteine on pregnancy: A systematic review

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Importantly, Retatrutide's unique triple receptor agonismtargeting GLP-1, GIP, and glucagon receptorsappears well-tolerated, with adverse events largely consistent with known effects from the broader GLP-1 class, primarily mild gastrointestinal symptoms such as nausea, decreased appetite, and occasional diarrhea, typically resolving within a few weeks of initiation