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This observation remains anecdotal but appears consistently across user reports

In addition to excessive intake of dietary supplements, parenteral administration of vitamin B12 may be another cause of excess, which is likely associated with an immune system response to produce anti-TC II antibodies

NAD+ Side Effects & Safety Commonly reported with SubQ Injection-site stinging, burning, redness, or temporary nodules managed with slow injection and site rotation

Yes, when supervised

These include: Vegetarians and Vegans: Since vitamin B12 is primarily found in animal products, those following a vegetarian or vegan diet may be at risk of deficiency