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Investigating Mechanisms in Humans: While preclinical studies have elucidated many molecular pathways, further research is needed to confirm if these mechanisms operate identically or with similar magnitude in human physiology
In an 8-week study using low-dose liraglutide (0.6 mg/day) in patients with type 2 diabetes no weight or fat loss was produced, but both fasting and postprandial glucose were substantially reduced, but neither fasting nor postprandial insulin (or C-peptide) response was increased [19]
33 Likewise, subsequent studies have revealed no treatment-related changes in REE or 24-h EE in obese individuals without T2DM after at least 14 weeks of treatment with the GLP-1 receptor agonist exenatide, 34, 35 or in REE in T2DM after 4 weeks of liraglutide treatment (2 weeks on 1.8 mg)
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