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Systemic administration produced equally impressive results: in cardiac ischemia models, doses ranging from 400 ng to 15 mg per animal reduced infarct size, improved myocardial function, and enhanced survival through activation of integrin-linked kinase and Akt pathways promoting cardiac cell migration and angiogenesis while preventing excessive fibrosis
Oxidation Dissolved oxygen in the reconstitution water can oxidize sensitive amino acid residues in the tirzepatide chain, particularly methionine and cysteine residues if present
It is investigated in experimental models for its interaction with growth factor signaling, angiogenesis-related mechanisms, and cytoprotective processes
Nat Rev Urol 21 , 433449 (2024)
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