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Some early data hints at modest changes, but this is not firmly settled, and B12 depletion is far more strongly linked to other medications (such as metformin) than to semaglutide
How long does it take for GLP-1 RAs (Semaglutide & Tirzepatide) to work
5.6 How Long Does It Take To See Results From Weight Loss Injections
Furthermore, in a 12-week RCT in which patients were either assigned to liraglutide (1.8 mg/day), sitagliptin (100 mg/day) or placebo, no difference in glycemic control or bodyweight reductions were found, and both treatments failed to reduce liver hepatic fat content compared to placebo (69)
Rybelsus (semaglutide) is the first FDA-approved oral GLP-1 agonist for patients with type 2 diabetes to improve blood sugar levels when combined with exercise and lifestyle changes
