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These categories include nucleic acids, proteins, lipids, carbohydrates, ions, metabolic byproducts, mitochondrial components, extracellular matrix (ECM) constituents (such as hyaluronic acid, heparan sulfate, matrilin-2 [MATN2], fibrinogen, hyaluronan, fibronectin, and enolase 1 [ENO1]), plasma components including complement (C3a, C4a, and C5a), intracellular molecules residing in various cellular regions such as cytosol, mitochondria, endoplasmic reticulum (ER), nucleus, and lysosome (including ATP, UA, and nucleotides), cell wall components (including peptidoglycan and -glucan), as well as cytokines and chemokines 197 (Fig

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Hepatoprotective effect of acetovanillone against methotrexate hepatotoxicity: Role of Keap-1/Nrf2/ARE, IL6/STAT-3, and NF-kappaB/AP-1 signaling pathways