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When to Seek Medical Advice About Medication Combinations Contact your GP or prescribing clinician before combining ibuprofen with Wegovy if you have : Kidney disease or impaired renal function NSAIDs can further compromise kidney performance History of peptic ulcers or gastrointestinal bleeding significantly increased risk with NSAID use Cardiovascular disease including heart failure, previous heart attack, or stroke Uncontrolled hypertension NSAIDs can elevate blood pressure Asthma some individuals experience NSAID-induced bronchospasm Liver disease affects metabolism of ibuprofen and paracetamol (semaglutide is not significantly affected by hepatic impairment) Taking anticoagulants warfarin (may require INR monitoring when starting semaglutide), DOACs, or antiplatelet agents increase bleeding risk with NSAIDs [2] Seek urgent medical attention if you experience : Severe abdominal pain particularly if sharp, persistent, or accompanied by vomiting Severe persistent upper abdominal pain radiating to the back potential sign of pancreatitis

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These are normal adaptive responses that occur with any significant weight loss, not specific tolerance to tirzepatide

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