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These warning signs include significant unexplained weight loss, severe abdominal pain, blood in stool, fever, persistent vomiting or symptoms of anaemia, such as fatigue and shortness of breath

Broens, Marja Kik, Henrich van der Lee, Sarah A

To generate Trim37 knockout PGCs in Nanog-EGFP transgenic embryos, we designed an sgRNA targeting exon 5 of Trim37 (Supplementary information, Fig