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GLP-1R is colocalized in 99% of the activated PSCs (shown by positive -SMA stain)
[1] [2] In terms of timeline, early changes in appetite and food intake may be noticed within the first two to four weeks of starting treatment, even at lower starting doses
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Men planning conception should be counseled that GLP-1 class agents are not currently recommended during fertility treatment due to insufficient reproductive safety data, per the FDA labeling precedent set for semaglutide and liraglutide [8]
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