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Retatrutide works through a triple receptor mechanism (GLP-1, GIP, and glucagon) while Ozempic activates only the GLP-1 receptor

[6] Preclinical studies in animal models suggest that GLP-1 receptor activation may: Promote neuroplasticity and neurogenesis (formation of new neurons) in the hippocampus, a region often showing reduced volume in depression Modulate neurotransmitter systems , particularly dopamine and serotonin pathways involved in mood regulation and reward processing Reduce neuroinflammation , which is increasingly recognised as contributing to depressive disorders Enhance brain-derived neurotrophic factor (BDNF) expression, a protein crucial for neuronal health and resilience Metabolic improvements associated with GLP-1 therapy may also contribute indirectly to mood benefits

Some studies indicate that l-carnitine supplementation leads to a rise in the levels of free carnitine and l-carnitine, especially among people having either a deficiency or a higher requirement of this amino acid

However, Ozempic only works for those who continue to use it

Following the 30-to-60-minute waiting period is essential for the medication to work