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Shah, G., Shimpi, R.K., Patankar, S., Chaudhari, M., & Sabale, V
SIRT1 is part of a family of proteins called sirtuins, known as longevity genes. It uses NAD+ as a fuel source to repair DNA, reduce inflammation, and improve stress resistance
( AMPK serves as a central energy sensor regulating hepatic fatty acid metabolism
The transcriptional factor HIF-1 induces glycolytic genes activation in response to hypoxia and growth factors
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