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The comparison between semaglutide, tirzepatide, and retatrutide shows that each successive generation of multi-receptor agonist delivers greater weight loss outcomes

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1 The GIPR association was specific to tirzepatide, Eli Lilly's dual GLP-1 and GIP receptor agonist sold as Mounjaro and Zepbound, with carriers of that variant found to be 83% more likely to experience vomiting than non-carriers

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