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The modified treatment-regimen estimand represents the estimated average treatment effect regardless of adherence to study intervention or initiation of prohibited weight management treatments, and assuming participants who took rescue orforglipron would not have received any additional improvement from their randomized study treatment

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Its worth noting that higher doses dont always mean better or faster results

M.DowdCA2001Structure, function and evolution of glutathione transferases: implications for classification of non-mammalian members of an ancient enzyme superfamily.360116 71

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