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The role of exercise in modulating ferroptosis to improve NDDs is definite (Figure 2), but its molecular mechanism still needs to be further elucidated
Svmi produkty pln podporuje Terapii bunn symbizy podle MuDr
Burns 48(7):15271543
However, in resistant patients, oxidative stress causes a conformational change in Keap1, leading to the release of NRF2, which translocates to the nucleus and binds to antioxidant response element (ARE), activating the expression of downstream antioxidant genes, including GPX4, NQO1, HO-1 and SOD1 [33], and promoting the synthesis of GSH, as illustrated in Fig
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