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While GLP1 receptor agonists have long been recognized for their glucose-lowering and weight-loss effects, they now offer potential for improving liver outcomes, especially in individuals with metabolic dysfunction-associated steatotic liver disease (MASLD) or its more advanced form, metabolic dysfunction-associated steatohepatitis (MASH)

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The main mechanisms of ferroptosis can be characterized in three aspects: the inhibition of the system X c -glutathione (GSH)glutathione peroxidase 4 (GPX4) axis, the elevation of iron metabolism axis, and the lipid metabolism (Figure 1)

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