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In humans, IGF-I also increases renal blood flow and GFR by ~25% and causes volume expansion and sodium retention by a direct action on the renal tubules, with stimulation of rennin release and suppression of atrial natriuretic peptide secretion[364]
It promotes an even skin tone and improves skin elasticity by combatting oxidative damage
Retrieved from [v] Higenamine: What Athletes Need to Know to Compete Clean: USADA
Ectopic NRF2 expression was achieved with pLenti-CMV-NFE2L2-Puro (#181919, Addgene)
To sum up, IGF-1 LR3 may boost all the anabolic effects of growth hormone and that is a powerful tool in terms of muscle mass and so on, but it does not directly raise GH levels, so could not be used for growth hormone deficiency
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