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The understanding of GLP-1 and its physiological functions has significantly advanced our approach to managing conditions related to glucose metabolism and obesity
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Another study found TMAO downregulates Piezo1, activating NOX4/ROS oxidative stress, causing abnormal calcium handling and fibrosis, constituting the molecular network of TMAO-induced cardiac fibrosis ( The above quadruple network links cardiac fibroblast proliferation, ER stress response, inflammatory signals and epigenetics, which together constitute the pathological basis of TMAO-induced fibrosis
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Moreover, A comprehensive approach addresses multiple factors contributing to gut dysfunction
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