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Early on, the shifts tend to be modest: a quieter inflammatory tone, slightly less morning stiffness, better tolerance of activities that used to aggravate the issue
But newer research revealed that GIP receptor activation in the brain actually reduces appetite, and when combined with GLP-1 receptor activation, the metabolic benefits multiply
Some patients report headache, changes in sleep patterns, mild nausea, or mood fluctuation during the first week
Mention it at your next routine appointment, and your doctor may suggest pausing the supplement and retesting
doi: 10.1016/j.gtc.2016.09.007
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