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1 Introduction Malignant melanotic nerve sheath tumors (MMNSTs), previously referred to as melanotic schwannomas (MS), are exceptionally rare neoplasms accounting for less than 1% of primary peripheral nerve sheath tumors ( For localized MMNST, treatment typically involves surgical resection (gross-total resection [GTR] or subtotal resection [STR]) combined with adjuvant radiotherapy ( VEGFR1/2/3 , c-Kit , PDGFR- , and FGFR , thereby disrupting tumor growth and survival signaling pathways ( 2 Case description A 54-year-old female presented with a right neck mass without other associated symptoms

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Interestingly, the combination of semaglutide and trevogrumab alone (without garetosmab) was better tolerated, with discontinuation rates similar to semaglutide monotherapy, suggesting that garetosmab may contribute to the increased side effects in the triplet regimen

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