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Current human data therefore cannot attribute fatigue, cold intolerance, or brain fog to altered T4-to-T3 conversion or validate a Free-T3-only monitoring rule. The obese trial cohorts lost roughly 8% of body weight at 1 mg in Phase 2 and about 28% at 12 mg in the 80-week Phase 3 trial

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A 2020 Nutrients review found no direct causal link but acknowledged nutrient imbalance risks

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