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Zhang QY, et al
Among participants in those trials who had been taking semaglutide or tirzepatide, the study found a mean weight regain of 9.69 kg (95% CI 5.7813.60) over the follow-up period (Berg et al., 2025)
A large-scale population-based study using administrative data from the Australian Institute of Health and Welfare reported a notable increase in the incidence of AP among adults, increasing from 37.56 to 52.09 cases per 100,000 person-years
However, the AngII/AT1 receptor system influences multiple functions beyond blood pressure, including body water balance, control of vasopressin and oxytocin release and sexual reproduction and behavior, thus undesirable drug-induced effects are possible
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