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CUL5-mediated visfatin (NAMPT) degradation blocks endothelial proliferation and angiogenesis via the MAPK/PI3K-AKT signaling
Likewise, PET-CT scans of mice fed a high-fat diet (HFD) showed that metformin increased glucose uptake on the basolateral side of the intestine, leading to enhanced glucose tolerance in a manner that depended on the dosage (Tobar et al., 2023)
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