Guide patients to check for the original, unsealed package
99% purity by HPLC and mass spectrometry is essential and C18 fatty acid hydrolysis products restoring the unconjugated peptide backbone, Aib8-to-Ala8 epimerisation products restoring DPP-IV sensitivity, linker hydrolysis fragments, and aggregated fatty acid conjugate species would show substantially altered GLP-1R binding kinetics, half-life pharmacokinetics, and downstream signalling profiles confounding quantitative receptor pharmacology and comparative biology studies
Vertical growth phase A growth phase characteristic of cutaneous melanoma that describes the invasive vertical growth deeper into the underlying tissue, which is associated with increased risk of metastasis
However, it is worth noting that the extent of the increase and the duration for which these elevated levels are maintained could vary between the two
There were early post-marketing reports of pancreatitis in a small number of patients on exenatide, which raised concern (especially around 20072008)