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Nonclinical Toxicology 13.1 Carcinogenesis, Mutagenesis, Impairment of Fertility In a 2-year carcinogenicity study in CD-1 mice, subcutaneous doses of 0.3, 1 and 3 mg/kg/day [9-, 33- and 113- fold the maximum recommended human dose (MRHD) of semaglutide tablet 14 mg, based on AUC] were administered to the males, and 0.1, 0.3 and 1 mg/kg/day (3-, 9- and 33-fold MRHD) were administered to the females

The gradual dose titration schedule is specifically designed to minimise gastrointestinal tolerability issues

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Glutathione is essential for Phase II liver detoxification, the process that tags used oestrogen metabolites for removal

it generates misleading data, compromises experimental timelines, and undermines the credibility of the entire peptide research field