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Pharmacological Reports, 73 , 1020
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Future GLP-2 trials in IBD should stratify patients by disease phenotype (mucosal UC, inflammatory CD, stricturing CD) and incorporate serial cross-sectional imaging to monitor for stricture progression, given the mechanistic link between GLP-2R signaling through subepithelial myofibroblasts and intestinal fibrogenesis
Free radicals are unstable molecules that can cause oxidative stressa process that can damage cells over time if left unchecked