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As isolated as an air-stable solid and available commercially, cobalt in vitamin B 12 (cyanocobalamin and other vitamers) is present in its +3 oxidation state

Additionally, the NNMT substrate nicotinamide 12 is metabolized by the microbiome 56,57 , and thus NNMTi may modulate substrate availability, potentially influencing microbial metabolic capacity to drive the NNMTi-mediated weight loss

Keep the compound in its original container or a suitable alternative that protects against moisture and light exposure

If you eat mostly plant-based foods, it is critical to supplement B12

That's where treatments like injectable B12 for humans come into play