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Dysregulation of the tyrosinase enzyme is the main cause of melanogenesis inhibition Hyperpigmentation is the darkening or increase in the natural color of the skin usually due to an increased deposition of melanin (hypermelanosis) Less frequently, it may be caused by the deposition in the dermis of endogenous or exogenous pigments, such as hemosiderin, iron, or heavy metals The excess of melanin in the basal and suprabasal layers of the skin is due to either an abnormally high number of melanocytes or a normal melanocyte population

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The laser illumination intensity was maintained at a minimum (0.1- 0.5% of the laser output) to avoid phototoxicity, and the pin hole was set such that an optical slice of 0.5 or 1 m was obtained

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Therapeutic effects of delta-sleep-inducing peptide (DSIP) in patients with chronic, pronounced pain episodes: A clinical pilot study