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Semaglutide (2.4mg, Wegovy): Approximately 14.9% body weight reduction over 68 weeks in the STEP trials

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Other 2026 Retatrutide Trials Several other Phase 3 studies have also reported encouraging results: TRIUMPH-4 (Obesity and Knee Osteoarthritis): Results released in December 2025 showed that participants receiving the 12 mg dose lost an average of 28.7% of their body weight after 68 weeks

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