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J.RedwoodS
The safety database, while extensive for clinical trials, represents limited duration and population diversity compared to the variability encountered in clinical practice
Nature 520 (7545), 5762
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And studies also found that chronic exposure to iron for mice caused a disorder of membrane-transport protein function and intracellular iron homeostasis and resulted in a significant increase in ROS and free radical MDA, ultimately leading to neuron and glial cell dysfunction and even neuron loss (Li L
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