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Second, the final maintenance dose may be lower than what you would use with retatrutide alone, because the cagrilintide component provides additional appetite suppression and metabolic benefit that reduces the need for maximum retatrutide dosing

There's also a known effect that patients with diabetes are more prone to depression

Quality of Life Improvement: Lastly, tirzepatide can significantly improve the quality of life for individuals with obesity and type 2 diabetes by reducing symptoms, such as fatigue, thirst, and frequent urination, associated with uncontrolled hyperglycemia

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doi: 10.3389/fpsyt.2026.1782761 Received 07 January 2026 Revised 18 March 2026 Accepted 18 March 2026 Published 13 April 2026 Volume 17 - 2026 Edited by Octavian Vasiliu, Carol Davila University Emergency Military Central Hospital, Romania Reviewed by Ju-Tae Sohn, Gyeongsang National University Hospital, Republic of Korea Vibha K