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These data point to some degree of refractoriness in the metabolic responses to this insulin sensitizer in our models, which could be consistently overcome by the treatment with GLP1/E, even at low-to-moderate doses

If successful, these options could reduce the aggregate number of devices required, which has led some industry stakeholders to consider them a sustainability lever

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Short-term use is rarely effective because the underlying physiological drivers of obesitysuch as hormonal imbalances in appetite regulationoften return once the medication is stopped