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This toxic substance is mainly created as a byproduct during glycolysis
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The critical caveat: the formal FDA reclassification has been announced but not yet published in the Federal Register as of mid-March 2026
Stras SF, Werner L, Toothaker JM, Olaloye OO, Oldham AL, McCourt CC, et al
Nevertheless, this theoretical concern means PTD-DBM should not be used by individuals with active or recent history of Wnt-pathway-associated cancers, particularly skin cancers in the treatment area
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