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Although ibuprofen is available over the counter, the FDA warns that it can cause serious side effects including stomach bleeding, kidney damage and cardiovascular complications especially when used at high doses or for long periods

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It requires minimal downtime and is generally less risky, making it a versatile solution

You can do all of that and end up with nothing, Raufman said

On one hand, it specifically activates the TLR2/NF-B signaling pathway [89], upregulates the expression of tight junction proteins, thereby effectively reducing intestinal permeability [25, 90, 91]