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For companies looking to manage the costs, the solution to the problem is just making it more difficult to get the drugs, Ameet Sarpatwari, a drug-pricing expert at Harvard, told me

Patients commonly report reduced appetite and earlier satiety, which are therapeutic effects mediated by GLP-1 and GIP receptor activation in appetite-regulating centers of the brain

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The sample size of patient is relatively small, and more comprehensive clinical characterization will require validation in larger cohorts