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Approximately 3 ml of whole blood was collected at each time point through the venous plexus of the forelimb

The release of GLP-1 follows a biphasic pathway: an initial peak mediated by neural signalling, followed by a second phase which is triggered by direct mechanical stimulation of L-cells, as nutrients pass through the gut (18)

Clinical studies have demonstrated significant improvements in skin density, wrinkle reduction, and accelerated healing of micro-injuries

At the same time, sustained receptor engagement may induce adaptive responses such as receptor desensitization, endocrine feedback suppression, or compensatory pathway activation

The resulting elevated TSH promotes thyroid gland enlargement, or goiter, with metabolic slowing in affected animals