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Effects on serotonergic and dopaminergic pathways noted
Slow-wave sleep was not increased consistently
Previously, it was thought that acetaminophen induces analgesia by inhibiting the enzyme cyclooxygenase (COX), but now it is believed that acetaminophen is metabolized to p -aminophenol, which crosses the blood-brain barrier and gets metabolized by fatty acid amide hydrolase to yield N -acylphenolamine (AM404)
The nasal mucosa provides reasonably good peptide absorption, bypassing digestive degradation while offering convenience
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