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Type 1 is an autoimmune disease in which insulin-producing -cells are attacked by the hosts immune system, and is thought to be caused by a combination of viral infection, an environmental trigger, or gene malfunction [3, 4]
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Additionally, GIP-mediated cAMP elevation activates exchange protein directly activated by cAMP 2 (Epac2), which stimulates ryanodine receptors (RYRs) on the endoplasmic reticulum to release stored calcium, further increasing cytosolic Ca concentration
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