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The severity of this initial inflammatory hit often correlates with downstream organ injury (for instance, peak IL-6 after cardiac surgery is a strong predictor of postoperative atrial fibrillation and AKI)

Of note, mouse dermal fibroblasts in unwounded skin expressed negligible luciferase and signal remained low in the first 3 days post-wounding

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If a cell does not heal enough fractures, it may die