In preclinical models, these mechanisms translate into broad potential applications, including wound healing, muscle and tendon repair, gastrointestinal ulcer protection, and recovery from NSAID-induced damage
doi: Walker EG, Lo KR, Pahl MC, et al
The Cu(II)/Cu(I) redox couple generates reactive oxygen species through the Fenton-like pathway: Cu(II) + O Cu(I) + O Cu(I) + HO Cu(II) + OH + OH Hydroxyl radicals (OH) are highly reactive and immediately oxidize susceptible amino acids
By inhibiting the cystine transporter (xCT), erastin inhibits the uptake of cystine
Akkermansia muciniphila colonization in the gut is inversely associated with obesity, diabetes, metabolic syndrome, and low-grade chronic inflammation