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In this line, the PVN integrates information from other hypothalamic nuclei involved in the modulation of hepatic functions [26] and sends signals both via intermediolateral nucleus in the spinal cord (sympathetic nervous system), and dorsal nucleus vagus in the brainstem (parasympathetic nervous system) [6, 31]
In addition, energy depletion inhibits mTORC1 by a mechanism that is independent of AMPK activation
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