The appetite suppression means you may train with less food in your system, which some find uncomfortable
In adults with type 2 diabetes, treatment with tirzepatide 5 mg, 10 mg and 15 mg once weekly was associated with superior weight reduction from baseline compared with placebo, semaglutide 1 mg weekly, titrated insulin degludec, titrated insulin glargine and titrated insulin lispro as an add-on to insulin glargine
10.1093/humrep/dem408 74 HaraguchiH.HirotaY.Saito-FujitaT.TanakaT.Shimizu-HirotaR.HaradaM.et al (2019)
It undergoes enzymatic processing from its preproglucagon peptide precursor within intestinal L-cells, ultimately giving rise to GLP-1(1-37) and peptide variants including GLP-1(7-36)
Prior studies have demonstrated superior weight-loss efficacy with higher doses of both agents, but direct comparisons have been limited and often restricted to specific dose combinations or populations without diabetes