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The critical role of glutathione in maintenance of the mitochondrial genome

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This balance influences numerous redox-regulated cellular processes, including the modulation of signaling pathways, post-translational modifications such as protein glutathionylation, activation of transcription factors like Nrf2 and NF-B, and the regulation of cell fate decisions such as proliferation or apoptosis [38]

Uncoupling protein 2 negatively regulates mitochondrial reactive oxygen species generation and induces phosphatase-mediated anti-inflammatory response in experimental visceral leishmaniasis