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Native IGF-1 has a frustrating pharmacokinetic limitation: it binds tightly to a family of IGF binding proteins (IGFBPs, particularly IGFBP-3) that sequester it in circulation and keep its free half-life to roughly 15-20 minutes

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After I received my first injection, I started experiencing nausea the same day, which continued for several days

Cell Rep (2017) 20(7):1692704

Administrar en ayuno o 1.5-2 h post-comida maximiza la magnitud del pulso GH sinrgico