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Split-APEX technology has been applied to mammalian cell membranes, noncoding RNA scaffolds, and mitochondria-associated endoplasmic reticulum contact sites [46]
Increased oxidation, impaired GSSG reduction, limited NADPH regeneration, reduced synthesis, and preanalytical artifacts can produce similar changes
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Patients should maintain regular contact with their GP or hepatology team to ensure appropriate surveillance and timely intervention when deficiencies or disease progression are detected
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